![]() ![]() Just one grapefruit or one glass of grapefruit juice could be enough to cause an interaction in some people. Grapefruit juice should not be contraindicated in people taking statins.ĭrug interaction Effect enhancer Grapefruit juice Ischemic heart disease LDL cholesterol Statins.Ĭopyright © 2016 Elsevier Inc. How much grapefruit is safe with atorvastatin The exact amount of grapefruit it takes to have a negative reaction when taking lovastatin, atorvastatin, or simvastatin is unknown. ![]() Essentially, compounds in grapefruit prevent the body. The increased rhabdomyolysis risk from grapefruit juice consumption due to the increased effective statin dose is minimal compared with the greater effect in preventing heart disease. Grapefruit and grapefruit juice can interact with some statins, leading to potentially dangerous results. Background: Grapefruit juice greatly increases the bioavailability of lovastatin and simvastatin. If the juice is taken 12 hours before these statins, the reductions are, respectively, 43% and 66%, and for atorvastatin, 42% and 66%. The interaction of Lipitor and grapefruit can occur even days after consuming either of them, since the enzymes and drugs can be in your system for an extended amount of time. When simvastatin or lovastatin are taken at the same time as grapefruit juice, the estimated reduction in LDL cholesterol is 48%, and in heart disease is 70%. When a body gains too much Atorvastatin there could be side effects such as muscle disorder or liver damage. Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin 10 mg daily reduce low-density lipoprotein (LDL) cholesterol levels in a 60-year-old man with an LDL cholesterol of 4.8 mmol/L by 37%, reducing ischemic heart disease risk by 61%. Greater increases in AUC (ratio of AUC up to 2.5) and/or C max (ratio of C max up to1.71) have been reported with excessive grapefruit consumption ( 750 mL to 1.2 liters per day). See Sections 5.1 and 7 for clinical significance. ATORVASTATIN AND GRAPEFRUIT PLUSA daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). &Represents ratio of treatments (co-administered drug plus Atorvastatin vs. This can increase the risk of side effects such as liver damage and a rare but serious. We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. Grapefruit juice can increase the blood levels of atorvastatin. ![]()
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